Table 11. Matrix of BINWOE Determinations for Hematological, Immunological, Neurological, (neuro)Developmental, Reproductive, Hepatic, and Carcinogenic Effects of Intermediate or Chronic Simultaneous Oral Exposure to Chemicals of Concern ON TOXICITY OF Strontium Cobalt Cesium Trichloroethylene PCBs
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چکیده
Examination of the available joint toxic action data, presented in Section 2.2, reveals that no health effects data are available for the complete mixture, or for ternary or quaternary submixtures. Because suitable data, joint action models, and PBPK models are lacking for the complete mixture, the recommended approach for the exposure-based assessment of joint toxic action of this mixture is to use a hazard index approach with a target-organ toxicity dose (TTD) modification and a qualitative weight-of-evidence (WOE) method. The WOE approach assesses the potential consequences of additive and interactive joint action of the components of the mixture on noncarcinogenic endpoints of concern (ATSDR 2001a). Table 11 presents a matrix of the BINWOE values, where available, for each of the component pairs of the chemicals of concern as discussed in Chapter 2. For each of the chemicals of concern, TTDs for oral exposure scenarios have been derived as described in the Appendices, using the methods recommended by ATSDR (2001a). Table 12 lists numerical values of these TTDs (and MRLs when available) for the endpoints of concern for chronic oral exposure to this mixture: hematological, immunological, reproductive, neurological, developmental, and hepatic effects.
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Table 10. Matrix of BINWOE Determinations for Neurological, Developmental, Reproductive, Renal, and Carcinogenic Effects of Intermediate or Chronic Simultaneous Oral Exposure to Chemicals of Concern ON TOXICITY OF Uranium Uranium Radiation
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